Apoptosis in rheumatoid arthritis synovium.
نویسندگان
چکیده
منابع مشابه
The Synovium in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune disease targeting multiple joints. The synovium is the primary site of the inflammatory process, which if untreated leads to irreversible damage to the adjacent cartilage and bone. It is now well established that autoantibodies that are characteristic of RA, including rheumatoid factor (RF) and anti-citrulluninated protein antibodies (ACPA), are...
متن کاملRheumatoid arthritis synovium contains plasmacytoid dendritic cells
We have previously described enrichment of antigen-presenting HLA-DR+ nuclear RelB+ dendritic cells (DCs) in rheumatoid arthritis (RA) synovium. CD123+HLA-DR+ plasmacytoid DCs (pDCs) and their precursors have been identified in human peripheral blood (PB), lymphoid tissue, and some inflamed tissues. We hypothesized recruitment of pDCs into the inflamed RA synovial environment and their contribu...
متن کاملCONCISE REPORT Low levels of apoptosis and high FLIP expression in early rheumatoid arthritis synovium
Objectives: To define synovial apoptosis with respect to disease duration, inflammatory cell type, FLIP (FLICE-like inhibitory protein), and cytokines expression in patients with rheumatoid arthritis (RA). Methods: Synovial biopsy specimens from 11 patients with longstanding RA (median disease duration 21 years) and eight with early RA (median disease duration five months) were investigated. Ap...
متن کاملSIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance.
OBJECTIVE To analyse the expression of SIRT1 in synovial tissues and cells of patients with rheumatoid arthritis (RA) and to study the function of SIRT1 in inflammation and apoptosis in RA. METHODS Levels of SIRT1 expression were analysed in synovial tissues and cells from patients with RA by real-time PCR and western blotting before and after stimulation with toll-like receptor ligands, tumo...
متن کاملCorrection: Cells of the synovium in rheumatoid arthritis. Chondrocytes
After publication of our recent article [1], we noticed an error in the third sentence of the third paragraph of the section entitled, 'Joint inflammation and cartilage remodeling in RA'. This sentence should read: ADAMTS-5 is expressed constitutively, whereas ADAMTS-4 is more prominently regulated by inflammatory cytokines.
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1995
ISSN: 0021-9738
DOI: 10.1172/jci118202